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Studies indicate that an insufficient supply of vitamin K2 may be associated with an increased risk of vascular calcification and bone loss

Glyburide, a second-generation sulfonylurea, was previously considered for gestational diabetes but has fallen out of favor due to concerns about neonatal hypoglycemia and possible increased birth weight

PLoS One 9 (9), e106841

In this respect, the BBB, BCSFB and meningeal barrier, especially the arachnoid barrier, are the three protective mechanisms [164, 165]

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According to the SmPC, nausea, vomiting, diarrhoea, and constipation are among the most frequently reported side effects, particularly during the initial weeks of treatment or following dose increases