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And in short that came out a few years after that STEP 1 trial what we did for the very first time is take individuals with obesity and pre-existing cardiovascular disease, like a prior stroke, prior heart attack, or peripheral arterial disease, called PAD, and they're on maximal therapy for their cardiovascular disease or stroke, and then randomized them on top of that to either semaglutide or placebo

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Moreover, it is known that in arteriosclerosis model mice, GLP-1 signaling increases the expression of eNOS which leads to the dilatation of blood vessel 8

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My suspicion would be that any benefit that somebody got from this would be much more likely due to a placebo effect than actual increased production of GLP-1, says Dr