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In addition, previous studies have shown that MG and D-lactic acid levels are significantly increased in aristolochic acid-induced and STZ-injected mouse models of kidney injury ( in vivo validation through targeted interventions It has been shown that MG is derived mainly from glycolysis ( 13 C-pyruvate tracing will delineate its fate in MG-rich microenvironments

Therefore, regarding surgical indications, the available evidence argues against a one-size-fits-all approach

There has been a growing concern in the use of complementary and alternative medicines, due to the having several unwanted effects associated with synthetic molecules and as a result more natural treatment options are in verge [8,9]

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Cholestatic injury is more likely to develop chronic liver injury, whereas mixed-pattern injury generally confers the most favorable prognosis