Song, P
Analysis of the SELECT trialassessing the cardiovascular impact of the diabetes and anti-obesity medication semaglutide (Wegovy, Novo Nordisk)has found that the use of the drug significantly reduced the risk of major adverse cardiovascular events (MACE) regardless of the amount of weight individuals lost
Its important to document when symptoms begin and how they progress
Several genes of chromosome 21 are directly implicated in oxidative stress, involving Cu, Zn-SOD (SOD1), ETS2 (ETS Proto-Oncogene 2) transcription factor, stress-inducible factor, protein S100, Down syndrome critical region gene 1 (DSCR1), amyloid precursor protein (APP), the -site APP cleaving enzyme 1 (BACE1) (Antonarakis et al
Within 10 years of T2DM diagnosis, 24.9% of people develop microalbuminuria, 5.3% develop macroalbuminuria, and 0.8% develop advanced CKD that includes persistently elevated plasma creatinine or the need for renal replacement therapy [4]
Additionally, gastrointestinal side effects including nausea, vomiting, and reduced fluid intake can lead to dehydration , which may precipitate acute kidney injury (AKI), particularly in vulnerable individuals