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The present review differentiates itself from prior studies through three principal innovations: (1) It provides a critical appraisal of current anti-obesity therapeutic strategies, identifying their pharmacological limitations and clinical shortcomings

At baseline, 64% patients were classified as NYHA class II, 35% class III and 1% class IV, median LVEF was 32%

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This underscores the necessity for diversified, disease-specific NAD + -targeting strategies (Liu et al

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