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A-T patients lack fully functioning ATM and are predisposed to a range of malignancies, radiation sensitivity, immunological and neurological disorders 56 caused by abnormalities in the cells response to DNA repair and elevated ROS levels particularly in neurons 57

Setting realistic expectations is crucial: weight loss is gradual, with clinical trials showing approximately 15% weight reduction with semaglutide 2.4 mg at 68 weeks and up to 21% with tirzepatide at 72 weeks, though individual responses vary considerably

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[DOI] [PubMed] [Google Scholar] Yamamoto S