Scenario 2: switching pharmacies mid-protocol You have been using a 2.5 mg/mL compounded vial
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To view a copy of this licence, visit About this article Cite this article van Houtum, W., Schrmbges, P., Amadid, H
For the primary composite outcome and secondary hierarchical outcomes, the threshold for two-sided statistical significance was set to 0.0322 (one-sided level 0.00161) using Lan-DeMets alpha spending function, which allows to adjust significance levels as data were reviewed for the interim analysis, reducing the chance of false positive results