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The Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) is a study comparing sitagliptin with placebo in diabetic patients with a previous history of cardiovascular disease

Similarly, medications for bone health or certain antibiotics may need timing adjustments to maintain efficacy

19 Of the agents currently available, dulaglutide, liraglutide and once weekly (OW) semaglutide have demonstrated CV benefits and have expanded indications from the US Food and Drug Administration (FDA) for use in people with T2D at high CV risk, based on the results of these trials

The first month I lost 10lbs, but lately I'm averaging about 1lb a week

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The evidence bases are comparable in quality and scale, with both lacking large-scale randomized therapeutic trials