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Permanent effects are rare and usually linked to misuse or unregulated products
101 Techniques are now broadly available for mutation analysis to be done as part of the diagnostic work-up of patients, and much work has also been done to try and identify a genotype/phenotype relationship, but to date, without significant success
Ricardo I
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The reduction of roGFP2(S 2 ) is therefore a good example for an enzyme using an alternative reaction pathway to overcome a kinetic challenge, and we hypothesize that other non-glutathione disulfide substrates with reactive proximal cysteinyl residues and rather negative redox potentials also require a ternary complex for their reduction
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