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Use of the arginine-depleting agent pegylated arginine deiminase ADI-PEG20 in GBM can increase nitric oxide (NO) synthesis and produce cytotoxic pernitrite, increasing the sensitivity of tumor cells to ionizing radiation and significantly enhancing the effect of radiotherapy on GBM

This deficiency can worsen common symptoms such as joint pain, fatigue, skin rashes, and digestive problems

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doi:10.1093/jn/124.suppl_8.1517S