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The mechanism of action of the DPP-4 inhibitors raises the question: Will these agents be effective in patients who have had diabetes for 10 to 15 years and who may no longer have any beta-cell function

Abstract The advent of incretin mimetics such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) has enriched the armamentarium for diabetes management owing to their glycaemic as well as extra-glycaemic benefits

All have found that GLP-1 treatment costs exceed healthcare savings

Trials vary by which molecule they use, what dose they give, and what population they study

Side Effects: As a GLP-1 therapy, common side effects are typically gastrointestinal, including nausea, vomiting, and diarrhea

The primary outcome was the first occurrence of a composite endpoint of non-fatal myocardial infarction, non-fatal stroke, or cardiovascular death