In this review, therapeutic strategies were divided into a therapeutic strategy focusing on the ferroptosis pathway and a therapeutic strategy focusing on metabolic vulnerability and nutrient addiction. However, mechanisms such as disulfide stress do not apply to either strategy
Washio K, Inagaki M, Tsuji M et al (2008) Oral vitamin C supplementation in hemodialysis patients and its effect on the plasma level of oxidized ascorbic acid and cu/Zn superoxide dismutase, an oxidative stress marker
For solving the crystal structures by PHASER 60 within the PHENIX software suite 61 , the co-crystal structure of PDEDeltazinone derivative with the PDB accession code 5E80 (chain A) was used as the model for molecular replacement
Due to this high aerobic demand, the generation of high amounts of ROS and other oxidative by-products is unavoidable ( GSH is synthesized via two ATP-dependent enzymatic steps catalyzed by glutamate-cysteine ligase (GCL) and glutathione synthetase
Also, a fundamental role of GSH has been recognized in the storage and transport of nitric oxide (NO), in the form of S-nitrosoglutathione (GSNO)
Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di (2-ethylhexyl) phthalate (DEHP) is associated with DNA methylation changes
