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Semaglutide and other GLP-1 receptor agonists produce weight loss by slowing stomach emptying and reducing appetite signaling in the brain

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Recommendations and precautions to be followed by healthcare professionals and patients for the safe and effective use of Ozempic have been included in the summary of product characteristics and the package leaflet

Key considerations include: Watching for signs of pancreatitis or gallbladder disease Looking at the patients overall health and medical history Changing the dosage or stopping treatment if side effects happen In patients with a history of gallbladder disease or cholecystectomy, the decision to start or keep using GLP-1 receptor agonist therapy should be made on a case-by-case basis