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therefore, their findings cannot be used to predict long-term cardiometabolic or cancer outcomes with confidence

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Therefore, there could be validity issues related to this and likely decreases generalizability of the study results

Safety Comparison# Key Differences Summary# Signaling bias : Ecnoglutide is cAMP-biased

Indeed, to achieve an intake of 10 g of L-citrulline, ingestion of around 35 kg of fresh watermelon (highest concentration of all foods) would be required and this is not only impractical for athletes (Davis et al

Acknowledgements This work was financially supported by the NSFC (T2422030 (WL), 82172081 (J.Q.) and 32471462 (J.Q.)), CAMS Initiative for Innovative Medicine (2021-I2M-1-043 (W.L.)), the Science and Technology Program of Tianjin, China (22JCYBJC01000 (W.L.) and 22JCQNJC01640 (J.Q.)), and the Fundamental Research Funds for the Central Universities (2021-RC350-006 (W.L.))