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Safety Advantage: Semaglutide The risk of serious side effects from GLP-1 receptor agonists is relatively low, but common side effects like nausea, indigestion, and other forms of GI upset can be expected by most users.6 These digestive issues tend to fade as your body adjusts to the medication and you make lifestyle adjustments based on how the medication affects your metabolism

One review of GLP-1 mechanisms showed reduced inflammatory markers and improved adipose tissue signaling in metabolic conditions, as seen in a recent research review

Tirzepatide trials showed 18 to 22% at the highest dose

Metformin has also been found to result in modest but clinically significant weight loss

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however, other reports raised concerns about a potential increase in thyroid cancer risk