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Upon binding on BCECs, the -glutamyl moiety on the surface of the nanoprobe was continually cleaved by GGT, which generated positively charged primary amines for triggering the AMT pathway

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Additionally, a family of enzymes expressed on the outer membrane of cells, gamma-glutamyl transpeptidases (GGTs), is involved in recycling extracellular glutathione, thereby contributing to de novo intracellular glutathione biosynthesis and ROS detoxification [14]

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Although the original branded product is no longer available, interest in Sermorelin has grown again in recent years