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The findings of some of the clinical trials in which lipoic acid administration has been tested in diabetic patients during the last 10 years are summarized

Derm Rev

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JMF4073 eliminates WT-Bcr-Abl-transformed myeloid cells in vitro and in vivo Since the balanced supply of dNTPs is critical for overcoming DNA damage and replication stress for cell survival, we then tested whether JMF4073 treatment could selectively suppress the growth of Bcr-Abl-transformed but not untransformed myeloid cells

This is then regenerated into BH4 with the help of 5-MTHF from the folate cycle

They may take you back down to a lower dose , at least temporarily , to see if that works better for you