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Likewise, the cardiovascular benefit of efpeglenatide was independent of GFR or the concomitant use of iSGLT-2, suggesting its additive and independent effect from the latter,85 as was also observed in the EXSCEL study.86 A recent meta-analysis of the 8 published cardiovascular safety clinical trials, and which included a total of 60

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Nagai, N., Kameda, N., Kobashi, R., Nishida, M., Horikawa, C., Egawa, K., Yoshimura, M., Kitagawa, Y., Abe, K., Kiso, Y., Sakane, N., Kotani, K., and Moritani, T