Personally, I tend to prefer options sweetened with stevia, monk fruit, or allulose, which are often used instead of artificial sweeteners
The former one which involved 6 COVTs (51,743 patients) showed that SGLT2 inhibitors reduced the risk of MACE (HR 0.93, 95% CI 0.871.00 and HR 0.82, 95% CI 0.710.96, respectively
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That last part matters because not everyone can take every drug class
Importantly, such variability does not negate biological relevance, but rather underscores the challenge of translating dynamic, context-sensitive endocrine signals into static biomarkers
Clinical trials reported that approximately 5-7% of participants discontinued treatment due to gastrointestinal side effects
