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GLP-1 RAs commonly cause gastrointestinal symptoms, and those symptoms increase at higher doses
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Additionally, null mutants in lin-45 /RAF, mek-2 /MEK, and mpk-1 /ERK enhance premature meiotic entry defect of a temperature-sensitive glp-1 loss-of-function allele at the permissive temperature, suggesting that MAPK signaling promotes SPC proliferation (Lee et al., 2007b)
Consumption of caffeinated coffee and a high carbohydrate meal affects postprandial metabolism of a subsequent oral glucose tolerance test in young, healthy males