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Other important side effects that may affect wellbeing include: Gallbladder problems (pain in the right upper abdomen, fever, jaundice) Dehydration leading to acute kidney injury, especially if vomiting or diarrhoea is severe Worsening of diabetic retinopathy in some patients, particularly with semaglutide Allergic reactions (rash, swelling, breathing difficulties) Patients should report suspected side effects to their healthcare provider and can also report them through the MHRA Yellow Card scheme