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Terkeltaub R, Banka CL, Solan J, Santoro D, Brand K, Curtiss LK

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demonstrated that amino acids and TCA cycle intermediates were elevated in ovarian cancer tissues ( via enhancing angiogenesis, and decreased cell adherence ( via an anaplerotic reaction of the TCA cycle intermediate -ketoglutarate, which contributes to redox balance and increase NADH production for the proliferation of cancer cells (59, 60)

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The heterogeneity of PCOS necessitates individualization of treatment options, and it appears that exercise combined with additional dietary/drug intervention is better for improving insulin sensitivity than either intervention alone [149,150,151]