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Although semaglutide and liraglutide show antidepressant and anxiolytic effects in animal models of depression and anxiety, in July 2023, the European Medicine Agency (EMA)s safety committee, the Pharmacovigilance Risk Assessment Committee (PRAC), was reviewing data on the risk of thoughts of suicide and self-harm associated with GLP-1 receptor agonists including semaglutide (Ozempic) and liraglutide (Saxenda) [26]

Because they are supplements rather than prescription medications, systemic side effects are less defined, but the lack of clinical testing means overall safety remains uncertain

Read professional profile DSIP Peptide UK Frequently Asked Questions Evidence-led answers about DSIP identity, sleep research, safety and UK regulation

Loop diuretics can increase urinary calcium, whilst thiazide diuretics may actually reduce calcium stone risk

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