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The GRAS determination was likely based on the compound's limited systemic absorption (when ingested), short plasma half-life, and lack of acute toxicity signals in the Phase 2b obesity trial
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IDO in the tumor microenvironment: inflammation, counter-regulation, and tolerance
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Most available studies are preclinical or conducted on small human samples, which limits the ability to conclusively state their long-term efficacy and safety
He M, Li X, Liu Y, et al
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