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These changes, along with its protein expression, significantly correlate with an increase in microvessel density, indicating that aberrant ubiquitination of HIF-1 may be linked to invasion and metastasis of VHL-deficient tumors[60]

The procedure was also performed under general anesthesia, which led to painful and prolonged recovery

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As detected by DCFH-DA and C11-BODIPY staining of frozen sections of the PDX tumors, the ROS levels and lipid peroxidation levels of the PDX tumors with high ACTL6A expression were lower, and they were significantly increased by BSO treatment