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In addition, the trials included in the meta-analysis were not designed to assess cancer outcomes

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The safety and effectiveness of this compound have not been fully evaluated in clinical trials, and its long-term effects are unknown

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Dialog Clin Neurosci 9:257272

As recently as 2024, Winfrey still wanted to believe she could control obesity with willpower, and skip medication Jastreboff has been leading obesity drug trials and treating patients with obesity for years as director of the Yale Obesity Research Center