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[10] [16] The most frequent side-effects of tirzepatide include nausea, vomiting, diarrhea, decreased appetite, constipation, upper abdominal discomfort, and abdominal pain

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If fatigue is persistent after the adaptation period, check whether total caloric intake has dropped below approximately 1,200 to 1,400 calories per day (the minimum for most people to maintain energy and lean mass)

Hyperactivity and impaired response habituation in hyperdopaminergic mice