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It would be interesting to elucidate the contribution of SLC7A11 to ferroptosis versus other forms of cell death (apoptosis, necrosis, autophagy) following inhibition in a variety of cancers

A randomized controlled pilot study of pentoxifylline in patients with non-alcoholic steatohepatitis (NASH)

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Primary antibodies, anti-Ki 67 (#sc23900, Santa Cruz Biotechnology, USA) and anti-phospho IRE1 alpha (p-IRE1) (#AF7150, Affinity Biosciences, USA) were applied at a 1:100 dilution for 3 h at RT

This metabolic adaptation can be relevant in triple-negative breast cancers (those lacking ERs, PRs and HER2, which constitute approximately a quarter of breast tumours) that express xCT, which exhibit increased levels of ROS induced by decreased glutamate levels upon glutamine scarcity