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doi: 10.1177/0272989X231196916 [DOI] [PMC free article] [PubMed] [Google Scholar] 25.Garvey WT, Mechanick JI, Brett EM, et al

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It causes reduced gut motility, delayed gastric emptying, and slowed digestion

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We assume that by the structure flexibility, shape, and different chemical function properties, thus, assure its reactivity and stability which outline the high affinity to M pro active site leveled by 14 interactions for example conventional hydrogen bond, carbonhydrogen bond, and sulfur bond, these interactions were saved in total acquired conformations, and the favored bonds were saved in both sides of aminopyrimidine and thiazolium ring linked by a methylene bridge with Asn142, Cys145, and Tyr54