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The exfoliating action of AHAs and BHAs can increase the penetration of glutathione, potentially causing irritation or dryness
This format supports reproducible handling, uniform exposure conditions, and reliable performance across nonclinical research workflows
The proposed mechanism involves controlling glutamate release in the synaptic cleft, modulating NMDA receptor stimulation, affecting excitatory amino acid transporter (EAAT)-mediated reuptake, and maintaining the glutamate/glutamine cycle within astrocytes
The phase 2 clinical trial will enroll 150 patients with CSU, who will receive either lesigercept or a placebo for a 12-week treatment period
The question is whether the science translated into a useful therapy
