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During illness, your needs increase due to: Fever can increase insensible fluid losses and may increase fluid needs (often estimated around 10% per 1C) Respiratory symptoms causing moisture loss through breathing Reduced thirst sensation from GLP-1 effects Potential vomiting or diarrhea Adequate hydration during illness helps thin mucus secretions, supports immune function, maintains blood pressure, and prevents medication-related complications

T.et al (2004)

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Thus, the inhibition of GLP-1R by exendin9-39 partly diminished the suppressive effects of exendin-4 on atrial fibrosis (Fig