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Lower tirzepatide doses (510mg weekly) reduce GI side effect burden while still providing meaningful appetite suppression, allowing researchers to maintain protocol adherence without the nausea and vomiting that causes 1015% of subjects to discontinue at higher doses

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Results Effect of Intravenous Ghrelin on GLP-1, GIP, and Insulin Release during an OGTT Ghrelin had no effect on basal GLP-1 levels, but glucose-stimulated GLP-1 secretion was found to be transiently increased in mice that had received intravenous administration of ghrelin (Figure 1A)

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