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3.4 Sarcopenia and functional impairment Sarcopenia and T2DM are becoming more widely acknowledged as linked disorders that have a substantial impact on quality of life and functional disability, especially in older populations

[PMID:28408076] Reino-Pires P, Pgo JM, Miranda A, et al

However, SOD-1 does inhibit proliferation and migration of smooth muscle cells induced by oxLDL in vitro (315), and overexpression of both SOD-1 and catalase reduce atherosclerosis in Apoe -/- mice (409)

The mechanism involves rapid weight loss triggering supersaturation of cholesterol in bile, combined with altered gallbladder motility from GLP-1 receptor activation, creating perfect conditions for stone formation and inflammation

Lancet, 398(10317), 2160-2172

Sirsch, D