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Dongiovanni P, Petta S, Mannisto V, Mancina RM, Pipitone R, Karja V, et al

EGCG can follow the mechanisms by which it can produce various effects including the upregulation of Bcl-2 associated X protein (Bax), a pro-apoptosis protein, the activation of caspases-3, -7 and -9, downregulation of proteins that inhibit apoptosis, or cell survival-promoting proteins (Bcl-2, D1 and cyclin-dependent kinase 2 (cdk2), and through the induction of tumor-suppressor proteins (p16INK4a, p21WAF1/CIP1, and p2KP1)

Much of this link has been associated with isothiocyanates, including sulforaphane (Mikus et al., 2020

Potential Risks and Side Effects Even with a strong safety profile, some users report minor side effects

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