Details As the publication indicates, previous studies have shown that "people receiving a standard weekly injection of the drug "Wegovy", which contains the active ingredient semaglutide, typically lose about 15% of their body weight within a year in combination with exercise and a healthy diet." The drug works by mimicking the action of the hormone glucagon-like peptide-1, or GLP1, which causes delayed gastric emptying and affects the brain, reducing appetite
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Nutrients, 2023;15(1):204
However, despite affinity, albeit lower, of tirzepatide for the GLP-1 receptor, tirzepatide had no effect on body weight, food intake, fasting insulin, endogenous glucose production and insulin-stimulated glucose uptake in skeletal muscle and subcutaneous white adipose tissue of GLP-1 receptor knockout mice [89]
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