Evid Based Complementary Altern Med
These functional improvements suggest that senescent cell clearance doesn't just change biomarkers it translates to measurable physical performance gains in aged animals
Its larger cross-trial weight number is a real and exciting signal, but ranking it above tirzepatide or semaglutide is an inference from non-comparable trials, not a finding
Additionally, females experienced greater pain relief than males, suggesting a potential gender-specific response to the treatment [62]
Taken with that caveat, it fits the idea that central GLP-1 receptor activity crosses an exposure threshold beyond which dopaminergic reward circuitry is damped enough to produce real depressive symptoms in vulnerable people ( 5.2 Neurobiological mechanism GLP-1 receptors in the hypothalamus, prefrontal cortex, and amygdala modulate serotonin, dopamine, and glutamate release
But cancer biology has made researchers cautious about any intervention that might increase the replicative capacity of somatic cells
