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These changes are related to the sodium-retaining properties of GH and IGF-1 via ENaC in the renal distal tubules ( vide supra ) and can be reversed if patients undergo effective treatment of the GH-producing tumor [100]

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It also appears to support angiogenesis and counteract the negative effects of corticosteroids on healing. However, despite over two decades of preclinical research, there is a paucity of clinical trials evaluating its use for musculoskeletal injuries in humans, and it remains unapproved for medical use by regulatory bodies. Collagen peptides do have human clinical data

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