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Quantitative analysis showed that intracellular oxLDL levels in cells treated with P-Mn/TI@mHSA were 5.63, 2.90, and 2.73 times lower than those in the PBS, Mn@mHSA, or P-Mn@mHSA groups, respectively (Fig

Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1

Lactate also regulates other immune cells in the TME, such as MDSCs and DCs

Therapeutic modulation of the microbiome shows promise: antibiotics targeting dysbiotic bacteria and fecal microbiota transfer (FMT) reduce lesion growth in preclinical models, while probiotics restoring Lactobacillus dominance improve NK cell activity and reproductive outcomes

A multiplex inhalation platform to model in situ like aerosol delivery in a breathing lung-on-chip

Dou Y, Lee A, Poon L, et al