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Gently apply to the face and neck

However, physiological levels of cortisol do not induce mineralocorticoid effects because 11-hydroxysteroid dehydrogenase type 2 (11-HSD2) inactivates cortisol into cortisone in tissues with high MR expression (1)

PMID: 46 DruckerDJ

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That does not establish a universal clinical outcome for every human patient

You must prioritize safety to reconstitute PT 141 at all times in order to maximize outcomes and minimize possible threats of this treatment approach