It can make the scale fluctuate by 2-5 pounds on any given day due to retained food and water, but this is not true weight gain
Additionally, MTX opposes thymidylate synthase [4]

Use With Caution In Research Models Involving: Diabetes or impaired glucose regulation Insulin resistance or metabolic syndrome Cardiovascular disease or uncontrolled hypertension Fluid-retention susceptibility or fluid-balancerelated conditions Hormonal or endocrine disorders Sleep apnea or significant respiratory disorders Chronic migraines or neurological sensitivity Kidney or liver impairment Avoid or Carefully Evaluate in Research Models With: Active or suspected malignancies History of growth-sensitive tumors Severe uncontrolled endocrine disorders Severe uncontrolled cardiovascular disease Pregnancy or breastfeeding contexts Known hypersensitivity to peptide compounds Additional Research Considerations Because Ipamorelin may increase endogenous growth hormone and downstream IGF-1 activity, research involving abnormal cellular proliferation, tumor-growth pathways, or uncontrolled metabolic disease should be approached with particular caution

Long-term glycine propionyl-l-carnitine supplemention and paradoxical effects on repeated anaerobic sprint performance
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It is a small protein just like insulin (called a peptide) and because proteins are easily broken down by stomach acids, which would make the protein inactive, both insulin and Trulicity (dulaglutide) need to be injected under the skin