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This absence of data is itself clinically significant it means that any combined use would occur without a formal safety profile for this specific pairing

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Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al

In practice this is described as rarely clinically significant

CJC-1295 DAC: CJC-1295 with drug affinity complex (DAC) technology contains an acetate that extends the longevity of CJC-1925 by up to five to eight days and increases insulin-like growth levels for up to 29 several days following a single dose [2]

Beyond supply and affordability, one of the bigger barriers to adoption has been that some patients just don't want to take an injection, says Ken Custer, executive vice president of Eli Lilly