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As demonstrated, PPP activation not only regulates the expression of Axl and MerTK but also supplies NADPH to sustain redox homeostasis under efferocytic stress but also regulates the expression of apoptotic cell sensors and maintains membrane fluidity, features that are intrinsically linked to efficient efferocytosis [89] (Fig
88 Similarly, a recent study of Schaaf KR reported that CFH was elevated in the airspace of most patients with ARDS and caused severe inflammation, and TLR4 on alveolar macrophages mediated the CFH-induced lung inflammation
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Renal tubular acidosis (RTA) represents a form of hyperchloremic metabolic acidosis and refers to pathologies that arise as a result of the failure of the kidneys to properly transport acid (H + ) into the tubular lumen for its excretion in the urine, or to retain HCO 3 under conditions of normal or slightly impaired glomerular filtration rate (GFR)
Only VCTE measurements based on at least 10 valid shots and success rates 60% were considered reliable and were used for statistical analysis
