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Sources: Hong S, Moreno-Navarrete JM, Wei X, et al
TCB II: 4247kDa protein Essential protein in the delivery of vitamin B12 to cells and tissues The production site of TCB II is primarily hepatocytic, and secondarily endothelial, monocytic and intestinal Functions of vitamin B12: B12 acts as a cofactor for two key enzymatic reactions: Methionine Synthase (cytoplasm): Converts homocysteine methionine Requires methylcobalamin Supports DNA synthesis via the folate cycle (regenerates tetrahydrofolate) Methylmalonyl-CoA Mutase (mitochondria): Converts methylmalonyl-CoA succinyl-CoA Requires adenosylcobalamin Involved in fatty acid and amino acid metabolism Elevated vitamin B12 (hypervitaminemia B12) While vitamin B12 deficiency is commonly discussed, elevated serum B12 (hypercobalaminemia) is less common and often overlooked or misinterpreted
Link: PubMed Article BPC-157 in Treating Inflammation Anti-inflammatory Effects of BPC-157 on Joint Pain and Chronic Inflammation. Published in Inflammation Research
Decreasing pain suggests inflammation resolving and tissue healing
All variants were classified as pathogenic apart from c.527924_527914del, which has been classified as likely pathogenic
