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The importance of W33 in small-molecule activation of GLP-1R was curious since it is located on the extracellular domain (ECD), distal from the transmembrane domains and connecting loops directly involved in peptide-induced GPCR activation ( 20, 32 )

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For the AMPK and adipocytokine/adiponectin pathways, recurrent nodes included G6PC, PPARG, and PPARGC1A, genes central to hepatic glucose regulation, adipose metabolism, and mitochondrial function, pathways consistently linked to GLP1RA metabolic benefits

Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells