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Conclusions In these studies, within the limitations of small sample sizes, no clinically relevant differences in cagrilintide pharmacokinetics were observed in participants with renal or hepatic impairment compared with those with normal function, suggesting that dose adjustment is not warranted for these populations

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[DOI] [PubMed] [Google Scholar] 101.Mamza J, Mehta R, Donnelly R, Idris I

The estrogen effect is route-dependent, occurring with oral delivery blunting the liver-mediated actions of GH by directly inhibiting GHR signaling