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323 Activation of TLRs triggers diverse signal transduction pathways, including myeloid differentiation primary response 88 (MyD88)-dependent and independent pathways (TRIF-dependent pathway), involving NF-B and MAPK signaling pathways, which regulate the release of multiple pro-inflammatory cytokines from neutrophils to initiate inflammatory responses

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Summary There is more to isoelectric point than just the calculation of pI values for individual amino acids