Symptoms mentioned in the reports include increased heart rate, fatigue, vomiting, loss of consciousness, and cardiac and respiratory arrest
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Srivastava, A
Along with widely accepted conventional mechanism of desensitization, studies of various GPCRs including dopamine D2-like receptors (D 2 R, D 3 R, D 4 R) have suggested the existence of another desensitization mechanism
When a major artery becomes partially blocked, collateral vessels that normally carry minimal blood flow can enlarge to compensate
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