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IGF-1 exerts its effects through the IGF-1 receptor, which activates a cascade of intracellular signaling pathways that promote cell growth and survival (Kenyon, 2010)

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A sub-cohort of the current cohort comprised 464 children and adolescents after excluding children with metabolic syndrome

Autism spectrum disorder (ASD) affects 1 in 44 children in the United States (Maenner et al., 2021), and is characterized by repetitive behaviors and issues with social interaction (Mughal et al., 2022)

Future cohort studies should consider the risk for reverse causation introduced by pancreatic cancer-related diabetes where the diabetes is paraneoplastic in response to the pancreatic tumor 46

Raghogarh-Vijaypur, Rupnagar, Naugachhia, Sendhwa, Byasanagar, Sandila, Gooty, Salur, Nanpara, Sardhana, Vita, Gumia, Puttur, Jalandhar Cantt., Nehtaur, Changanassery, Mandapeta, Dumka, Seohara, Umarkhed, Madhupur, Vikramasingapuram, Punalur, Kendrapara, Sihor