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Repeated insufflation can cause: Chronic irritation, crusting, and nosebleeds infections of the nasal mucosa and sinuses Damage to the nasal septum, sometimes progressing to a perforation (a literal hole) that can whistle, impair airflow, or deform the bridge

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Gently feel up and down the wrapper to ensure it is smoothly packed, with no lumps or weak points

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concomitant use of other medications that lower the seizure threshold (e.g., other bupropion products, antipsychotics, tricyclic antidepressants, theophylline, and systemic corticosteroids)

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