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Variants in genes like GLP1R (rs6923761), GIPR (rs1800437), and MC4R (rs17782313) affect how sensitively your brain responds to GLP-1 signaling and how strongly your body drives caloric intake when medication stops

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Semaglutide is approved for weight loss in patients without diabetes High-dose semaglutide is the most effective of the available weight-loss drugs thus far